Introduction –

Research programs that are part of Academic Medical Centers (AMC) are uniquely positioned to accelerate the translation of research into clinical care. The central role of a clinician scientist in the AMC drives innovation from the viewpoint of health and disease. An organizational structure supporting basic, clinical and translational research creates a natural pipeline for innovation from fundamental biological discoveries to long-term health outcomes. Like many other factors affecting the healthcare system, artificial intelligence (AI) is fast becoming a significant disruptor to the traditional academic research model and more specifically, the translational research model which focuses on the translation of scientific discovery and innovation to clinical and health impact. This paper highlights some of the critical challenges that AMC-based research programs face and new opportunities presented, and introduces a framework outlining key steps AMCbased research organizations will need to take to prepare for AI and develop their programs.